ApeWorX, also known as "Ape," is a Python-based smart contract development and deployment framework that seeks to succeed the Brownie framework, offering enhanced customizability and secure private key management. ApeWorX distinguishes itself by dividing networks into ecosystems and chains, such as Ethereum or Fantom, and requires plugins for functionality like Solidity compilation and network access, ensuring a tailored development environment. It improves security by encrypting private keys locally, requiring a password for access, thus preventing accidental exposure on platforms like GitHub. ApeWorX supports familiar Python testing practices with tools like pytest and provides a command-line interface for project initialization and management. The framework is gaining traction among Python enthusiasts and DeFi protocols, offering a collaborative environment for contributors familiar with Vyper and Brownie.