Bazel, an open-source build system developed by Google, is particularly favored for its speed, correctness, and reproducibility, and is used by many large engineering teams for constructing multi-language builds. This guide offers a practical walkthrough for integrating Bazel into Python projects, showcasing the setup and configuration of a basic Python app and library using Bazel's MODULE.bazel files. It highlights Bazel's use of Starlark for defining builds and its action graph for mapping dependencies, ensuring efficient and hermetic builds. The guide explains the process of creating Python build targets using BUILD.bazel files, covering definitions for libraries, executables, and tests, and demonstrates Bazel's capabilities in managing dependencies, including Python versions and third-party libraries through extensions like rules_python. Additionally, the document touches on the advantages of using Bazelisk for managing Bazel installations and emphasizes the benefits of using Buildkite in conjunction with Bazel for advanced build and deployment workflows, offering tools for uploading libraries, identifying flaky tests, and more. The guide encourages further exploration of Bazel's functionalities and its integration with Buildkite for enhanced project management and CI/CD processes.