Playwright is an open-source framework designed for end-to-end testing, allowing users to run tests across multiple browsers and operating systems using a single API. It supports major web browsers like Chromium, Firefox, and WebKit, ensuring cross-browser compatibility. Setting up Playwright involves installing Node.js, downloading Playwright and its dependencies, and writing tests using its built-in test runner and automation API. For scalability and reliability, cloud-based platforms such as LambdaTest can facilitate Playwright testing across various environments, reducing infrastructure costs and accelerating release cycles. Various methods, including UI mode, headed mode, and CI/CD integration, allow for flexible testing strategies, and Playwright supports parallel test execution for improved efficiency. Additionally, the framework integrates with AI for smarter test creation and maintenance, making it a versatile tool for software quality assurance professionals.